If you are an artist, you can do anything you want. It’s perfectly all right. Design serves a different purpose. If in the process of solving a problem you create a problem, obviously, you didn’t design.
When people talk about typographic grids it often revolves around the horizontal and aligning elements to columns of precise widths. The vertical gets slighted at times due to the dynamic heights of web pages.
However, we shouldn’t ignore the vertical. We should set the vertical to a baseline grid.